11-beta hydroxysteroid dehydrogenase-1 (corticosteroid 11-beta-dehydrogenase isozyme 1, 11-DH, 11-beta-HSD1, HSD11B1, HSD11, HSD11L)

Function: - catalyzes reversibly conversion of cortisol to inactive metabolite cortisone - catalyzes conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol; in intact cells, reaction runs only in one direction (putative) 11-beta-hydroxysteroid + NADP⁺ 11-oxosteroid + NADPH Structure: - homodimer (putative) - glycosylated - belongs to the short-chain dehydrogenases/reductases (SDR) family Compartment: - endoplasmic reticulum membrane Expression: - widely expressed - ighest expression in liver Pathology: - defects in HSD11B1 are a cause of cortisone reductase deficiency

General

11-OH steroid dehydrogenase; corticosteroid 11-beta dehydrogenase glycoprotein membrane protein

Properties

SIZE: entity length = 292 aa MW = 32 kD COMPARTMENT: endoplasmic reticulum MOTIF: transmembrane domain {8-24} cofactor-binding site [34-67] COFACTOR-BOUND: NADP N-glycosylation site {N123} N-glycosylation site {N162} binding site SITE: 170-170 FOR-BINDING-OF: Substrate tyrosine residue {Y183} cofactor-binding site [187-187] COFACTOR-BOUND: NADP N-glycosylation site {N207}

Database Correlations

OMIM correlations UniProt P28845 Pfam PF00106 ENZYME 1.1.1.146

References

UniProt :accession P28845