zyxin (zyxin-2)

Function: 1) adhesion plaque protein 2) binds alpha-actinin & the CRP protein 4) mediates adhesion-stimulated changes in gene expression (putative) 5) interacts, via the Pro-rich regions, with EVH1 domains of ENAH & VASP, important for targeting to focal adhesions & formation of actin-rich structures Structure: - contains 3 LIM zinc-binding domains Compartment: - cytoplasm, cytoskeleton - associates with the actin cytoskeleton near adhesion plaques Pathology: - interacts with HPV type 6 protein E6 - does not interact significantly with E6 proteins from HPV types 11, 16, or 18

General

cytoskeletal adhesion protein phosphoprotein

Properties

SIZE: MW = 61 kD entity length = 572 aa COMPARTMENT: cytoplasm MOTIF: proline-rich region SITE: 64-77 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 94-108 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 115-121 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 127-137 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S259} Ser phosphorylation site {S267} Ser phosphorylation site {S281} Ser phosphorylation site {S290} Ser phosphorylation site {S344} LIM domain {384-443} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {444-503} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {504-570} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site

Database Correlations

OMIM 602002 UniProt Q15942 Pfam PF00412

References

UniProt :accession Q15942