zinc finger protein ZXDC (ZXD-like zinc finger protein, ZXDC, ZXDL)

Function: - cooperates with CIITA to promote transcription of MHC class 1 & MHC class 2 genes - self-associates - interacts with ZXDA & CIITA Structure: - belongs to the ZXD family - contains 10 C2H2-type zinc fingers Compartment: nucleus Alternative splicing: named isoforms=2 Expression: expressed in heart, kidney, liver, testis > brain, stomach > lung, muscle, placenta, small intestine, spleen

Properties

SIZE: MW = 90 kD entity length = 858 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 175-199 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 208-232 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 238-262 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 268-290 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 297-321 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 328-352 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 358-382 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 388-412 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 418-442 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 451-476 EFFECTOR-BOUND: Zn+2 transcriptional activation domain SITE: 579-688 CIITA interaction {781-858}

Database Correlations

UniProt Q2QGD7 Pfam PF00096

References

UniProt :accession Q2QGD7