zona pellucida sperm-binding protein 4 (zona pellucida sperm-binding protein B, ZP4, ZPB)

Function: 1) one of 3-4 glycoproteins comprising zona pellucida 2) ZP4 may act as a sperm receptor Structure: - proteolytically cleaved before transmembrane segment to yield secreted ectodomain incorporated in zona pellucida - belongs to the ZP domain family, ZPB subfamily - contains 1 P-type domain (trefoil domain) - contains 1 ZP domain, involved in polymerization of ZP proteins to form zona pellucida Compartment: - cell membrane - processed form: secreted, extracellular matrix Expression: oocytes

General

glycoprotein membrane protein

Properties

SIZE: MW = 59 kD entity length = 540 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-18} N-glycosylation site {N69} P-type {142-182} ZP domain {188-466} MOTIF: cysteine residue {*1} MODIFICATION: cysteine residue {*2} cysteine residue {*2} MODIFICATION: cysteine residue {*1} N-glycosylation site {N202} N-glycosylation site {N219} N-glycosylation site {N267} Thr glycosylation site {T302} N-glycosylation site {N470} N-glycosylation site {N474} transmembrane domain {506-526}

Database Correlations

UniProt Q12836 PFAM correlations

References

UniProt :accession Q12836