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zinc finger protein 382; KRAB/zinc finger suppressor protein 1; KS1; multiple zinc finger & krueppel-associated box protein KS1 (ZNF382)
Function:
- sequence-specific transcriptional repressor (putative)
- interacts with TRIM28
- enhances the transcriptional repressor activity (putative)
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 10 C2H2-type Zn+2 fingers
- contains 1 KRAB domain
Compartment: nucleus (putative)
Alternative splicing: named isoforms=3
Expression:
- specifically expressed in heart
- weaker expression in skeletal muscle
- primarily detected in 34 day-old embryos
- widely expressed at different levels during embryonic development
- in the embryo, expressed in cerebellum, kidney, cerebrum > lung, heart, skeletal muscle, tongue, adrenal gland
General
C2H2 type zinc finger protein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 550 aa
MW = 64 kD
COMPARTMENT: cell nucleus
MOTIF: TRIM28 interactions {1-105}
MOTIF: Represses transcription {5-46}
Krueppel-associated box
NAME: Krueppel-associated box
SITE: 7-78
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
Represses transcription {70-211}
Zn finger C2H2-type
SITE: 212-234
EFFECTOR-BOUND: Zn+2
DNA-binding motif
SITE: 296-550
MOTIF: Zn finger C2H2-type
SITE: 296-318
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 324-346
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 352-374
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 380-402
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 408-430
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 436-458
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 464-486
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 492-514
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 520-542
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 609516
UniProt Q96SR6
Pfam PF01352
Entrez Gene 84911
Kegg hsa:84911
References
- UniProt :accession Q96SR6
- Entrez Gene :accession 84911