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zinc finger protein 365; protein su48 (ZNF365, KIAA0844)
Function:
- phosphorylated upon DNA damage, probably by ATM or ATR
- homodimer
- interacts with NDE1 & NDEL1
- does not interact with TUBG1
Compartment:
- cytoplasm, cytoskeleton, centrosome
- localizes to the centrosome at all stages of the cell cycle
Alternative splicing: named isoforms=6
Expression:
- isoform 1 is expressed in brain
- isoform 2 is expressed in placenta > lung, liver
- isoform 3 is expressed in kidney, pancreas
Comparative biology:
- isoform 4 (talanin) of ZNF365 does not exist in rodents (see talanin)
Specific
talanin
General
zinc finger protein
Properties
SIZE: MW = 47 kD
MW = 24 kD
entity length = 407 aa
entity length = 216 aa
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
coiled coil {169-297}
MOTIF: Thr phosphorylation site {T205}
Database Correlations
OMIM 607818
SWISS-PROT correlations
Pfam PF00096
Entrez Gene 22891
References
- Entrez Gene :accession 22891
- UniProt :accession Q70YC4, Q70YC5