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zinc finger protein 346; just another zinc finger protein (ZNF346, JAZ)
Function:
1) binds to dsRNA & DNA (zinc-finger dependent)
2) forms a heteromeric complex with XPO5 & ILF3
3) found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 & double-stranded RNA
4) interacts with XPO5
5) interacts with ILF3 (RNA-independent)
Structure:
- contains 4 matrin-type zinc fingers
Compartment:
- nucleus, nucleolus, cytoplasm
- shuttles between the nucleus & cytoplasm when associated with XPO5
Alternative splicing: named isoforms=2
General
C2H2 type zinc finger protein
Properties
SIZE: MW = 33 kD
entity length = 294 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Zn finger matrin-type
NAME: Zn finger matrin-type
SITE: 70-104
EFFECTOR-BOUND: Zn+2
Zn finger matrin-type
NAME: Zn finger matrin-type
SITE: 131-165
EFFECTOR-BOUND: Zn+2
Zn finger matrin-type
NAME: Zn finger matrin-type
SITE: 182-216
EFFECTOR-BOUND: Zn+2
Zn finger matrin-type
NAME: Zn finger matrin-type
SITE: 236-270
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 605308
UniProt Q9UL40
References
- Entrez Gene :accession 93666
- UniProt :accession Q9UL40