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zinc finger protein 202; zinc finger protein with KRAB & SCAN domains 10 (ZNF202, ZKSCAN10)
Function:
- transcriptional repressor
- binds to elements found predominantly in genes that participate in lipid metabolism
- among its targets are
a) structural components of lipoprotein particles (apolipoproteins apoA4, apoC3, & apoE)
b) enzymes involved in lipid processing
- lipoprotein lipase
- lecithin-cholesteryl ester transferase
c) transporters involved in lipid homeostasis (ABCA1, ABCG1)
d) several genes involved in processes related to energy metabolism & vascular disease
- interacts with SDP1
Structure:
- contains 8 C2H2-type Zn+2 fingers
- contains 1 KRAB domain
- contains 1 SCAN box domain
Compartment: nucleus
Alternative splicing:
- named isoforms=2; alpha
Expression:
- highly expressed in testis
Pathology:
- also expressed in breast carcinoma cell lines
General
C2H2 type zinc finger protein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 648 aa
MW = 75 kD
COMPARTMENT: cell nucleus
MOTIF: scan box (LeR) {46-127}
MOTIF: leucine residue (SEVERAL)
Krueppel-associated box
NAME: Krueppel-associated box
SITE: 237-308
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 397-419
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 425-447
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 481-503
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 509-531
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 537-559
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 565-587
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 593-615
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 621-643
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 603430
UniProt O95125
PFAM correlations
Entrez Gene 7753
Kegg hsa:7753
References
- UniProt :accession O95125
- SeattleSNPs
http://pga.gs.washington.edu/data/znf202/