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zinc finger protein 148; zinc finger DNA-binding protein 89; transcription factor ZBP-89 (ZNF148, ZBP89)
Function:
- role in transcriptional regulation
- represses the transcription of a number of genes including gastrin, stromelysin & enolase
- binds to the G-rich box in the enhancer region of these genes
- interacts with HNRPDL
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 4 C2H2-type Zn+2 fingers
Compartment: nucleus
General
C2H2 type zinc finger protein
phosphoprotein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 794 aa
MW = 89 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 171-193
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 199-221
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 227-249
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 255-278
EFFECTOR-BOUND: Zn+2
Thr phosphorylation site {T305}
Ser phosphorylation site {S306}
Ser phosphorylation site {S412}
Database Correlations
OMIM 601897
UniProt Q9UQR1
Pfam PF00096
Entrez Gene 7707
Kegg hsa:7707
References
UniProt :accession Q9UQR1