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protein kinase C-binding protein 1; cutaneous T-cell lymphoma-associated antigen se14-3; CTCL-associated antigen se14-3; Rack7; zinc finger MYND domain-containing protein 8 (ZMYND8, KIAA1125, PRKCBP1, RACK7)
Function:
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts in vitro with PRKCB1
Structure:
- contains 1 bromo domain
- contains 1 MYND-type Zn+2 finger
- contains 1 PHD-type Zn+2 finger
- contains 1 PWWP domain
Alternative splicing: named isoforms=9
Expression:
- expressed in all tissues examined
- highest expression in brain, lung, pancreas, & placenta
Pathology:
- expressed in cutaneous T-cell lymphomas (CTCL)
General
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 1186 aa
MW = 132 kD
MOTIF: lysine-rich region {43-47}
MOTIF: lysine residue (SEVERAL)
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 88-133
EFFECTOR-BOUND: Zn+2
bromodomain {165-235}
PWWP domain {277-327}
Ser phosphorylation site {S406}
Ser phosphorylation site {S460}
Ser phosphorylation site {S462}
Ser phosphorylation site {S465}
Ser phosphorylation site {S486}
Ser phosphorylation site {S488}
Ser phosphorylation site {S490}
Ser phosphorylation site {S495}
Thr phosphorylation site {T541}
Ser phosphorylation site {S547}
Ser phosphorylation site {S652}
Ser phosphorylation site {S655}
Ser phosphorylation site {S668}
Ser phosphorylation site {S756}
Thr phosphorylation site {T760}
glutamine-rich region {838-854}
MOTIF: glutamine residue (SEVERAL)
Zinc finger
NAME: Zinc finger
SITE: 1028-1062
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S1086}
serine-rich region {1089-1092}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S1089}
Thr phosphorylation site {T1093}
PRKCB1 interaction {1147-1186}
Database Correlations
UniProt Q9ULU4
PFAM correlations
Entrez Gene 23613
Kegg hsa:23613
References
UniProt :accession Q9ULU4