Zinc fingers & homeoboxes protein 2 (zinc finger & homeodomain protein 2, alpha-fetoprotein regulator 1, AFP regulator 1, regulator of AFP, ZHX2, AFR1, KIAA0854, RAF)

Function: 1) transcriptional repressor 2) forms homodimers 3) forms heterodimers with ZHX1 & ZHX3 4) heterodimerization with ZHX1 not necessary for repressor activity 5) interacts with NFYA Structure: 1) belongs to the ZHX family 2) contains 2 C2H2-type zinc fingers 3) contains 4 homeobox DNA-binding domains Compartment: nucleus Expression: ubiquitously expressed

General

phosphoprotein zinc finger protein

Properties

SIZE: MW = 92 kD entity length = 837 aa COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S16} Zn finger C2H2-type SITE: 78-101 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 110-133 EFFECTOR-BOUND: Zn+2 homodimerization {195-358} MOTIF: homeodomain SITE: 263-324 required for interaction with NFYA {263-497} MOTIF: repressor {263-446} nuclear localization {317-446} homeodomain SITE: 439-501 homeodomain SITE: 530-591 homeodomain SITE: 628-690

Database Correlations

UniProt Q9Y6X8 PFAM correlations

References

UniProt :accession Q9Y6X8