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zinc fingers & homeoboxes protein 1 (ZHX1)
Function:
1) transcriptional repressor
2) forms heterodimers with ZHX3, prerequisite for repressor activity
3) forms homodimers
4) forms heterodimers with ZHX2
5) interacts with NFYA
Structure:
1) belongs to the ZHX family.
2) contains 2 C2H2-type zinc fingers
- contains 5 homeobox DNA-binding domains
Compartment: nucleus
Expression: ubiquitously expressed
General
zinc finger protein
Properties
SIZE: MW = 98 kD
entity length = 873 aa
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T36}
Zn finger C2H2-type
SITE: 70-93
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 102-125
EFFECTOR-BOUND: Zn+2
NFYA {272-564}
MOTIF: dimerization {272-432}
homeodomain
SITE: 284-346
homeodomain
SITE: 464-526
homeodomain
SITE: 569-630
Ser phosphorylation site {S648}
homeodomain
SITE: 660-722
nuclear localization {734-768}
homeodomain
SITE: 777-832
repressor {831-873}
Database Correlations
OMIM 604764
UniProt Q9UKY1
Pfam PF00046
References
UniProt :accession Q9UKY1