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zinc finger FYVE domain-containing protein 27 (ZFYVE27)
Function:
- interacts with SPAST/spastin
Structure:
- contains 1 FYVE-type zinc finger
Compartment: membrane, punctate vesicles
Alternative splicing: named isoforms=5
Pathology:
- defects in ZFYVE27 associated with spastic paraplegia type 33
General
glycoprotein
transmembrane 3c protein
zinc finger FYVE domain-containing protein (ZFYVE)
Properties
SIZE: MW = 46 kD
entity length = 411 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-66}
transmembrane domain {67-87}
exoplasmic loop {88-88}
transmembrane domain {89-109}
cytoplasmic loop {110-187}
transmembrane domain {188-208}
exoplasmic domain {209-411}
MOTIF: N-glycosylation site {N209}
proline-rich region
SITE: 246-249
MOTIF: proline residue (SEVERAL)
Zn finger Fyve-type
SITE: 344-410
EFFECTOR-BOUND: Zn+2
Database Correlations
UniProt Q5T4F4
Pfam PF01363
References
UniProt :accession Q5T4F4