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zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain, ZFYVE19, MPFYVE)
Structure:
- contains 1 FYVE-type zinc finger
Alternative splicing: named isoforms=3
Expression:
- expressed in brain, heart, skeletal muscle, kidney, liver
Pathology:
- chromosomal translocation t(11;15)(q23;q14) involving ZFYVE19 with MLL/HRX is associated with acute myeloblastic leukemia (AML)
General
zinc finger FYVE domain-containing protein (ZFYVE)
Properties
SIZE: MW = 52 kD
entity length = 471 aa
MOTIF: Zn finger Fyve-type
SITE: 74-133
EFFECTOR-BOUND: Zn+2
BREAKPOINT FOR TRANSLOCATION TO FORM MLL- ZFYVE19 {145-146}
coiled coil {311-375}
glutamate-rich region {412-417}
MOTIF: glutamate residue (SEVERAL)
cysteine-rich region {421-444}
Database Correlations
UniProt Q96K21
Pfam PF01363
References
UniProt :accession Q96K21