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zinc finger protein 161 homolog; Zfp-161; zinc finger protein 5; HZF5; zinc finger & BTB domain-containing protein 14 (ZFP161, ZBTB14)
Function:
- transcriptional repressor of c-Myc & thymidine kinase promoters (putative)
- transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'
Structure:
- the BTB/POZ domain seems to direct the protein to discrete regions in the nucleus
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 1 BTB/POZ domain
- contains 5 C2H2-type Zn+2 fingers
Compartment: nucleus
General
C2H2 type zinc finger protein
DNA-binding protein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 449 aa
MW = 51 kD
COMPARTMENT: cell nucleus
MOTIF: BTB domain {36-102}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
nuclear translocation signal {50-66}
acidic region {154-179}
MOTIF: acidic residue (SEVERAL)
Zn finger C2H2-type
SITE: 277-304
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 305-332
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 333-360
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 361-388
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 389-417
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 602126
UniProt O43829
PFAM correlations
Kegg hsa:7541
References
UniProt :accession O43829