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rocuronium (Zemuron)
Tradename: Zemuron.
Indications:
1) inpatient & outpatient use as an adjunct to general anesthesia
2) rapid-sequence & routine endotracheal intubation
3) skeletal muscle relaxation during surgery or mechanical ventilation
Dosage:
1) induction 0.6 mg/kg IV bolus
2) infusion: 0.01-0.012 mg/kg/min after early evidence of spontaneous neuromuscular function is evident
Injection: 10 mg/mL ( 5 mL, 10 mL).
Pharmacokinetics:
1) good intubating conditions in 1-3 minutes
2) maximum neuromuscular blockade in 3-4 minutes
3) duration of action: 7-70 minutes
4) minimal hepatic metabolism
5) excreted primarily by the biliary secretion
Adverse effects:
1) not common (> 1%)
- transient hypotension & hypertension
2) uncommon (< 1%)
- arrhythmias, abnormal EKG, tachycardia, nausea/vomiting, bronchospasm, wheezing, rhonchi, hiccups, rash, edema at site of injection, pruritus
3) other
- respiratory acidosis, hypomagnesemia, hypokalemia, & hypocalcemia may enhance the actions of rocuronium
- dehydration may alter effects of rocuronium
Drug interactions:
1) aminoglycosides, clindamycin, quinidine, magnesium sulfate, verapamil, furosemide
2) reduction in maintenance & infusion of enflurane or isoflurane may be necessary
Interactions
drug interactions
General
neuromuscular blocker (paralyzing agent)
Properties
MISC-INFO: elimination route LIVER
pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998