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transcriptional repressor protein YY1; Yin & yang 1; YY-1; delta transcription factor; NF-E1 (YY1)
Function:
- multifunctional transcription factor
- positive & negative control on a large number of cellular & viral genes through binding to sites overlapping the transcription start site
- role in development & differentiation
- function of YY1 as an activator or a repressor is specified by the presence of other proteins; acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence
- interacts with YAF2 through the region encompassing the first & second Zn+2 fingers
Structure:
- belongs to the YY transcription factor family
- contains 4 C2H2-type Zn+2 fingers
Compartment:
- nuclear matrix
- associated with the nuclear matrix
Related
YY1 gene mutation
General
C2H2 type zinc finger protein
phosphoprotein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 414 aa
MW = 45 kD
COMPARTMENT: cell nucleus
MOTIF: acidic region {43-53}
MOTIF: acidic residue (SEVERAL)
glycine-rich region {54-69}
histidine-rich region {70-80}
MOTIF: histidine residue (SEVERAL)
Ser phosphorylation site {S118}
serine-rich region {159-170}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S184}
Ser phosphorylation site {S247}
Involved in nuclear matrix association {257-341}
MOTIF: Zn finger C2H2-type
SITE: 296-320
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 325-347
EFFECTOR-BOUND: Zn+2
Involved in repression of activated transcription {333-371}
MOTIF: Thr phosphorylation site {T348}
Zn finger C2H2-type
SITE: 353-377
EFFECTOR-BOUND: Zn+2
transcriptional activation domain
SITE: 371-397
Zn finger C2H2-type
SITE: 383-407
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 600013
UniProt P25490
Pfam PF00096
Entrez Gene 7528
Kegg hsa:7528
References
- UniProt :accession P25490
- Sui G, Affar el B, Shi Y, Brignone C, Wall NR, Yin P,
Donohoe M, Luke MP, Calvo D, Grossman SR, Shi Y.
Yin Yang 1 is a negative regulator of p53.
Cell. 2004 Jun 25;117(7):859-72.
PMID: 15210108