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14-3-3 protein zeta/delta; protein kinase C inhibitor protein 1; KCIP-1 (YWHAZ)
Function:
- adapter protein implicated in regulation of both general & specialized signaling pathways
- binds to many protein, usually by recognition of a phospho-Ser or phospho-Thr motif
- binding generally results in modulation of the activity of the binding partner
- isoform delta differs from isoform zeta in being phosphorylated (putative)
Structure:
- homodimer.
- belongs to the 14-3-3 family
Compartment:
- cytoplasm, melanosome
Note:
- originally thought to have phospholipase A2 activity [2]
General
14-3-3 protein (KCIP-1)
Properties
SIZE: entity length = 245 aa
MW = 28 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S184}
Thr phosphorylation site {T232}
Database Correlations
OMIM 601288
UniProt P63104
Pfam PF00244
Kegg hsa:7534
References
- UniProt :accession P63104
- Zupan LA, Steffens DL, Berry CA, Landt M, Gross RW.
Cloning and expression of a human 14-3-3 protein mediating
phospholipolysis. Identification of an arachidonoyl-enzyme
intermediate during catalysis.
J Biol Chem. 1992 May 5;267(13):8707-10.
PMID: 1577711