14-3-3 protein theta; 14-3-3 protein tau; 14-3-3 protein T-cell; protein HS1 (YWHAQ)

Function: - adapter protein implicated in regulation of both general & specialized signaling pathways - binds to many protein, usually by recognition of a phospho-Ser or phospho-Thr motif - binding generally results in modulation of the activity of the binding partner - interacts with PCTK1 (putative). - interacts with SSH1 Structure: - homodimer - belongs to the 14-3-3 family Compartment: - cytoplasm - in neurons, axonally transported to the nerve terminals Expression: - abundantly expressed in brain, heart & pancreas, & at lower levels in kidney & placenta Pathology: - up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis; highest expression in patients with predominant lower motor neuron involvement

Properties

SIZE: entity length = 245 aa MW = 28 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl binding site SITE: N-TERMINAL FOR-BINDING-OF: 14-3-3 protein Ser phosphorylation site MOTIF-SEQUENCE: SPEK Ser phosphorylation site binding site FOR-BINDING-OF: raf1 proto-oncogene protein FOR-BINDING-VIA: Zinc finger

Database Correlations

OMIM 609009 UniProt P27348 Pfam PF00244 Kegg hsa:1097

References

UniProt :accession P27348