14-3-3 protein eta; protein AS1 (YWHAH YWHA1)

Function: - adapter protein implicated in regulationboth general & specialized signaling pathways - binds to many protein, usually by recognition of a phospho-Ser or phosphot-Thr motif - binding generally results in modulation of activity of the binding partner - interacts with RGNEF (putative) - interacts with many nuclear hormone receptors & cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP & THRA Structure: - homodimer. - belongs to the 14-3-3 family Expression: - expressed mainly in the brain & present in other tissues albeit at lower levels

Properties

SIZE: entity length = 246 aa MW = 28 kD MOTIF: Tyr phosphorylation site {Y117}

Database Correlations

OMIM 113508 UniProt Q04917 Pfam PF00244 Kegg hsa:7533

References

UniProt :accession Q04917