14-3-3 protein beta/alpha; protein kinase C inhibitor protein 1; KCIP-1; protein 1054 (YWHAB)

Function: - adapter protein implicated in the regulation of both general & specialized signaling pathways - binds many protein, usually by recognition of a phospho-Ser or phospho-Thr motif - binding generally results in the modulation of the activity of the binding partner - isoform alpha differs from isoform beta in being phosphorylated (putative) - isoform short contains a N-acetylmethionine at position 1 - interacts with SSH1 & TORC2/CRTC2 Structure: - homodimer - belongs to the 14-3-3 family - contains a N-acetylmethionine at position 1 Compartment: - cytoplasm - melanosome Alternative initiation: named isoforms=2

General

14-3-3 protein (KCIP-1) enzyme inhibitor metalloprotein

Properties

SIZE: entity length = 246 aa MW = 28 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S186}

Database Correlations

OMIM 601289 UniProt P31946 Pfam PF00244 Kegg hsa:7529

References

UniProt :accession P31946