YEATS domain-containing protein 4 (glioma-amplified sequence-41, Gas41, NuMA binding protein 1, NuBI-1, NuBI1, YEATS4, GAS41)

Function: - component of the NuA4 histone acetyltransferase (HAT complex) - component of numerous complexes with chromatin remodeling & histone acetyltransferase activity - component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, TCFL1/YL1 & YEATS4/GAS41 - YEATS4 interacts with MLLT10/AF10 - YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 & TACC2, & the nuclear matrix protein NUMA1 Structure: contains 1 YEATS domain Compartment: nucleus Expression: - expressed in brain, heart, kidney, liver, lung, pancreas, placenta & skeletal muscle

Properties

SIZE: entity length = 227 aa MW = 26 kD COMPARTMENT: cell nucleus MOTIF: YEATS {22-126} MLLT10 interaction {163-227} MOTIF: TACC1 interaction {168-227} coiled coil {178-226}

Database Correlations

OMIM 602116 UniProt O95619 Pfam PF03366 Kegg hsa:8089

References

UniProt :accession O95619