non-homologous end-joining factor 1 (protein Cernunnos, XRCC4-like factor, NHEJ1, XLF)

Function: 1) DNA repair protein involved in DNA nonhomologous end joining in DNA double-strand break repair & V(D)J recombination 2) bridge between XRCC4 & other factors located at DNA ends 3) interacts with XRCC4 Compartment: nucleus Alternative splicing: named isoforms=2 Expression: ubiquitously expressed Pathology: - defects in NHEJ1 are a cause of combined immune deficiency Notes: - named 'Cernunnos' after the Celtic god of hunt, underworld & fertility

Properties

SIZE: MW = 33 kD entity length = 299 aa COMPARTMENT: cell nucleus

References

UniProt :accession Q9H9Q4