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xanomeline

Indications: - used in combination with tropsium for treatment of schizophrenia Adverse effects: - cholinergic adverse effects Mechanism of action: - muscarinic receptor agonist - no dopamine receptor antagonist activity

General

muscarinic receptor agonist

References

  1. Shekhar A et al. Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry 2008 Aug; 165:1033. PMID: 18593778
  2. Brannan SK, Sawchak S, Miller AC et al Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia. N Engl J Med 2021; 384:717-726 Feb 25 PMID: 33626254 https://www.nejm.org/doi/full/10.1056/NEJMoa2017015B

Component-of

tropsium chloride/xanomeline (Cobenfy, KarXT)