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procaine penicillin (Wycillin)
Tradename: Wycillin. 1st generation penicillin.
Indications:
1) moderately severe infections due to Neisseria gonorrhoeae
2) syphilis
Dosage:
1) adults
a) 0.6-4.8 x 10E6 U/day IM divided QD-BID
b) uncomplicated gonorrhea:
1] probenecid 1 g PO
2] 4.8 x 10E6 U procaine PCN divided in 2 separate IM injection sites 30 minutes later
c) Streptococcus viridans endocarditis
1] 1.2 x 10E6 U IM every 6 hours for 2-4 weeks
2] used in conjunction with an aminoglycoside
2) children:
a) 25-50,000 U/kg/day IM divided QD-BID
b) gonorrhea:
1] probenecid 25 mg/kg up to 1 g PO
2] 100,000 U/kg divided in 2 separate IM injection sites 30 minutes later
Injection: 600,000 units (1 mL, 2 mL, 4 mL).
Pharmacokinetics:
1) time to peak serum concentration: 1-4 hours
2) 60-90% is excreted unchanged in the urine by tubular secretion
3) 30% of the drug is metabolized & inactivated in the liver
4) elimination delayed in neonates, young infants & patients with renal insufficiency
5) moderately dialyzable: 20-50%
Adverse effects:
1) common (> 10%)
- pain at injection site
2) uncommon (< 1%)
- CNS stimulation, seizures, myocardial depression, vasodilation, cardiac conduction disturbances, confusion, drowsiness, hemolytic anemia, positive direct antiglobulin (Coomb's) test (DAT), sterile abscess at site of injection, myoclonus, interstitial nephritis, pseudoanaphylactic reactions, Jarisch-Herxheimer reaction, hypersensitivity reactions
Interactions
drug interactions
Related
Bicillin CR
General
penicillin G
Properties
MISC-INFO: elimination route KIDNEY
pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
Component-of
Bicillin CR