Wilms' tumor 1-associating protein; pre-mRNA-splicing regulator WTAP; Female-lethal(2)D homolog; hFL(2)D; WT1-associated protein (WTAP KIAA0105)

Function: - regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability - impairs WT1 DNA-binding ability & inhibits expression of WT1 target genes - may be involved in mRNA splicing regulation - phosphorylated upon DNA damage, probably by ATM or ATR - interacts with WT1 Structure: belongs to the fl(2)d family Compartment: nucleus, nucleolus Alternative splicing: named isoforms=2 Expression: - ubiquitously expressed - in smooth muscle cells, up-regulated after serum withdrawal, when cells become mature & non proliferative

Related

Wilm's tumor; nephroblastoma Wilms' tumor protein; WT1 protein (WT1, WT3)

General

phosphoprotein splicing factor; snRNP-associated protein

Properties

SIZE: entity length = 396 aa MW = 44 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S244} Ser phosphorylation site {S305} Ser phosphorylation site {S306}

Database Correlations

OMIM 605442 UniProt Q15007 Entrez Gene 9589 Kegg hsa:9589

References

UniProt :accession Q15007