WD repeat & SOCS box-containing protein 1; WSB-1; SOCS box-containing WD protein SWiP-1 (WSB1, SWIP1)

Function: - probable substrate-recognition component of an elongin-Cullin-SOCS-box protein (ECS) E3 igase complex which mediates the ubiquitination & subsequent proteasomal degradation of target proteins - recognizes type II iodothyronine deiodinase/DIO₂ - confers constitutive instability to HIPK2 through proteasomal degradation - protein modification; protein ubiquitination - interacts with DIO₂ - component of probable ECS(WSB1) E3 ubiquitin ligase complex - interacts with CUL5, RNF7, TCEB1 & TCEB2 - binds to HIPK2 through WD40 repeats Structure: - the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (putative) - contains 1 SOCS box domain - contains 6 WD repeats Alternative splicing: named isoforms=3

Related

SOCS box domain WD repeat

Properties

SIZE: MW = 47 kD entity length = 421 aa MOTIF: WD repeat {32-71} WD repeat {124-165} WD repeat {168-208} WD repeat {212-251} WD repeat {254-293} WD repeat {309-346} SOCS box domain {372-421}

Database Correlations

OMIM 610091 UniProt Q9Y6I7 PFAM correlations Entrez Gene 26118 Kegg hsa:26118

References

UniProt :accession Q9Y6I7