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wnt7A proto-oncogene protein
Function:
- ligand for members of the frizzled family
- probable developmental protein
- signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (putative)
- interacts with PORCN (putative)
- when secreted by cerebellar granule cells, induces axonal remodeling & synaptic differentiation in mossy fibers
- regulates synapsin 1 accumulation
Structure: belongs to the Wnt family
Compartment:
- secreted, extracellular space, extracellular matrix
Expression:
- restricted to placenta, kidney, testis, uterus, fetal lung, & fetal & adult brain
Pathology:
- defects in WNT7A are the cause of
a) limb/pelvis-hypoplasia/aplasia syndrome
b) Fuhrmann syndrome
General
wnt proto-oncogene protein or int proto-oncogene protein
Properties
SIZE: entity length = 349 aa
MW = 39 kD
MOTIF: signal sequence {1-31}
N-glycosylation site {N83}
N-glycosylation site {N127}
N-glycosylation site {N295}
Database Correlations
OMIM correlations
MORBIDMAP 601570
UniProt O00755
Pfam PF00110
Entrez Gene 7476
References
- Hall et al. Cell 100:525-35, 2000
- Entrez Gene :accession 7476
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=WNT7A
- UniProt :accession O00755