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wnt4 proto-oncogene protein
Function:
- required for Mullerian duct formation
- in the developing ovary, appears to suppress development of Leydig cells
- ligand for members of the frizzled family
- probable developmental protein
- may be a signaling molecule which affects the development of discrete regions of tissues
- likely to signal over only few cell diameters (putative)
- overexpression may be associated with abnormal proliferation in human breast tissue
- interacts with PORCN (putative)
Structure: belongs to the Wnt family
Compartment:
- secreted, extracellular space, extracellular matrix
Pathology:
- defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome
General
wnt proto-oncogene protein or int proto-oncogene protein
Properties
SIZE: entity length = 351 aa
MW = 39 kD
MOTIF: signal sequence {1-22}
N-glycosylation site {N88}
N-glycosylation site {N297}
Database Correlations
OMIM correlations
MORBIDMAP 603490
UniProt P56705
Pfam PF00110
Entrez Gene 54361
Kegg hsa:5436
References
- Vainio et al. Nature 397:405-9 1999
- Entrez Gene :accession 54361
- UniProt :accession P56705