protein Wiz (widely-interspaced zinc finger-containing protein, zinc finger protein 803, WIZ, ZNF803)

Function: - may link EHMT1 & EHMT2 histone methyltransferases to the CTBP corepressor machinery - role in EHMT1-EHMT2 heterodimer formation & stabilization (putative) - interacts with EHMT1, EHMT2, CTBP1 & CTBP2 Structure: - belongs to the krueppel C2H2-type zinc-finger protein family - contains 11 C2H2-type zinc fingers C2H2-type zinc finger 11 mediates interaction with EHMT1 & EHMT2 Compartment: nucleus Alternative splicing: named isoforms=2

General

C2H2 type zinc finger protein phosphoprotein

Properties

SIZE: MW = 179 kD entity length = 1651 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 267-289 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 304-326 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 353-375 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 416-439 EFFECTOR-BOUND: Zn+2 glutamate-rich region {567-576} MOTIF: glutamate residue (SEVERAL) glutamine-rich region {624-629} MOTIF: glutamine residue (SEVERAL) Zn finger C2H2-type SITE: 701-723 EFFECTOR-BOUND: Zn+2 lysine-rich region {753-757} MOTIF: lysine residue (SEVERAL) Zn finger C2H2-type SITE: 769-791 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 870-892 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S1012} Ser phosphorylation site {S1017} CTBP1/CTBP2 interaction {1030-1034} Zn finger C2H2-type SITE: 1043-1065 EFFECTOR-BOUND: Zn+2 proline-rich region SITE: 1096-1178 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S1127} CTBP1/CTBP2 interaction {1214-1218} Zn finger C2H2-type SITE: 1227-1249 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1397-1419 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1596-1622 EFFECTOR-BOUND: Zn+2

References

UniProt :accession O95785