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WNT1-inducible-signaling pathway protein 1; WISP-1; Wnt-1-induced secreted protein (WISP1 CCN4)
Function:
- downstream regulator in the Wnt/Frizzled-signaling pathway
- associated with cell survival
- attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase
- up-regulates the anti-apoptotic Bcl-X(L) protein
- adheres to skin & melanoma fibroblasts
- in vitro binding to skin fibroblasts occurs through the proteoglycans, decorin & biglycan
Structure:
- belongs to the CCN family
- contains 1 CTCK (C-terminal cystine knot-like) domain
- contains 1 IGFBP N-terminal domain
- contains 1 TSP type-1 domain
- contains 1 VWFC domain
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine & spleen
- isoform 2 is weakly expressed in placenta
Pathology:
- overexpression is associated with several cancers including: breast cancer & colon tumors
- isoform 2 is overexpressed in scirrhous gastric carcinoma
General
WNT1 inducible signaling pathway protein
Properties
SIZE: entity length = 367 aa
MW = 40 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
IGFBP N-terminal {40-118}
MOTIF: N-glycosylation site {N86}
VWFC domain {121-186}
MOTIF: N-glycosylation site {N143}
TSP1 module {215-260}
C-terminal cystine knot {273-347}
MOTIF: cysteine residue {C273}
MODIFICATION: cysteine residue {C310}
N-glycosylation site {N284}
cysteine residue {C290}
MODIFICATION: cysteine residue {C324}
cysteine residue {C301}
MODIFICATION: cysteine residue {C340}
cysteine residue {C304}
MODIFICATION: cysteine residue {C342}
cysteine residue {C309}
MODIFICATION: cysteine residue {C346}
cysteine residue {C310}
MODIFICATION: cysteine residue {C273}
cysteine residue {C324}
MODIFICATION: cysteine residue {C290}
cysteine residue {C340}
MODIFICATION: cysteine residue {C301}
cysteine residue {C342}
MODIFICATION: cysteine residue {C304}
N-glycosylation site {N343}
cysteine residue {C346}
MODIFICATION: cysteine residue {C309}
Database Correlations
OMIM 603398
UniProt O95388
PFAM correlations
Entrez Gene 8840
Kegg hsa:8840
References
- UniProt :accession O95388
- Entrez Gene :accession 8840