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WINAC complex
Function:
- chromatin-remodeling complex recruited by vitamin D receptor
- required for the ligand-bound vitamin D receptor mediated transrepression of the CYP27B1 gene
Structure:
- subunits: SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A & TOP2B
General
molecular complex
Properties
SUBUNITS: global transcription activator SNF2L2
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S175}
glutamine-rich region {216-238}
MOTIF: glutamine residue (SEVERAL)
glutamine-rich region {245-253}
MOTIF: glutamine residue (SEVERAL)
Ser phosphorylation site {S329}
HSA {436-508}
arginine-rich region {559-562}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S591}
glutamate-rich region {643-650}
MOTIF: glutamate residue (SEVERAL)
helicase
NAME: helicase
SITE: 736-901
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 749-756
DEAD/H box
NAME: DEAD/H box
SITE: 851-854
Ser phosphorylation site {S956}
Helicase C-terminal {1054-1216}
glutamate-rich region {1297-1301}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1377}
Ser phosphorylation site {S1410}
Ser phosphorylation site {S1418}
bromodomain {1419-1489}
MOTIF: Ser phosphorylation site {S1419}
Ser phosphorylation site {S1512}
Ser phosphorylation site {S1516}
glutamate-rich region {1518-1529}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1528}
Ser phosphorylation site {S1568}
Ser phosphorylation site {S1572}
Ser phosphorylation site {S1582}
Ser phosphorylation site {S1585}
Thr phosphorylation site {T1587}
transcription activator BRG1
COMPARTMENT: cell nucleus
MOTIF: SS18L1/CREST interaction {1-282}
MOTIF: Thr phosphorylation site {T11}
HSA {460-532}
lysine-rich region {578-588}
MOTIF: lysine residue (SEVERAL)
Thr phosphorylation site {T609}
Ser phosphorylation site {S610}
Ser phosphorylation site {S613}
Ser phosphorylation site {S655}
Ser phosphorylation site {S657}
Ser phosphorylation site {S660}
Ser phosphorylation site {S662}
glutamate-rich region {663-672}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S695}
Ser phosphorylation site {S699}
Ser phosphorylation site {S721}
helicase
NAME: helicase
SITE: 766-931
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 779-786
DEAD/H box
NAME: DEAD/H box
SITE: 881-884
Helicase C-terminal {1084-1246}
glutamate-rich region {1360-1364}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1382}
Ser phosphorylation site {S1452}
bromodomain {1477-1547}
MOTIF: peptide motif {1539-1540}
Ser phosphorylation site {S1570}
glutamate-rich region {1571-1584}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1575}
Ser phosphorylation site {S1586}
Ser phosphorylation site {S1627}
Ser phosphorylation site {S1631}
Ser phosphorylation site {S1640}
Ser phosphorylation site {S1642}
Ser phosphorylation site {S1644}
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
COMPARTMENT: cell nucleus
MOTIF: binding site
SITE: 106-183
FOR-BINDING-OF: deoxyribonucleic acid (DNA)
MOTIF: Ser phosphorylation site {S129}
binding site
SITE: 183-243
FOR-BINDING-OF: HIV-1 INTEGRASE
tandem repeats {186-319}
MOTIF: consensus repeat {186-245}
binding site
SITE: 186-245
FOR-BINDING-OF: myc protein family
consensus repeat {259-319}
PPP1R15A interaction {304-318}
SWI/SNF complex subunit SMARCC1
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S301}
Ser phosphorylation site {S310}
Ser phosphorylation site {S319}
Ser phosphorylation site {S328}
proline-rich region
SITE: 329-336
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S330}
Thr phosphorylation site {T335}
Thr phosphorylation site {T337}
Ser phosphorylation site {S339}
Ser phosphorylation site {S357}
SWIRM {449-546}
Ser phosphorylation site {S573}
SANT {618-669}
glutamate-rich region {769-863}
MOTIF: glutamate residue (SEVERAL)
alanine-rich region {867-878}
MOTIF: alanine residue (SEVERAL)
coiled coil {914-946}
proline-rich region
SITE: 977-1105
MOTIF: proline residue (SEVERAL)
SWI/SNF complex subunit SMARCC2
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {186-189}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S283}
Ser phosphorylation site {S286}
Tyr phosphorylation site {Y296}
Ser phosphorylation site {S302}
Ser phosphorylation site {S304}
Ser phosphorylation site {S306}
Thr phosphorylation site {T322}
Ser phosphorylation site {S347}
SWIRM {424-521}
SANT {596-647}
glutamate-rich region {747-855}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S806}
Ser phosphorylation site {S810}
alanine-rich region {861-870}
MOTIF: alanine residue (SEVERAL)
coiled coil {907-934}
glutamine-rich region {956-960}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 961-1213
MOTIF: proline residue (SEVERAL)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
COMPARTMENT: cell nucleus
MOTIF: multiple interactions {43-167}
MOTIF: lysine-rich region {124-127}
MOTIF: lysine residue (SEVERAL)
SMARCC1/SMARCC2 interaction {168-474}
domain {180-515}
MOTIF: SWIB {291-390}
coiled coil {412-440}
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 5-65
MOTIF: proline residue (SEVERAL)
HMG box
SITE: 66-134
coiled coil {220-319}
MOTIF: Ser phosphorylation site {S265}
glutamate-rich region {320-411}
MOTIF: glutamate residue (SEVERAL)
actin-like protein 6A
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S233}
bromodomain adjacent to zinc finger domain protein 1B
COMPARTMENT: cell nucleus
MOTIF: WAC {20-126}
lysine-rich region {306-578}
MOTIF: lysine residue (SEVERAL)
coiled coil {533-586}
DDT {604-668}
Ser phosphorylation site {S705}
Ser phosphorylation site {S708}
coiled coil {768-814}
coiled coil {850-893}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1184-1234
EFFECTOR-BOUND: Zn+2
coiled coil {1245-1283}
MOTIF: glutamate-rich region {1261-1273}
MOTIF: glutamate residue (SEVERAL)
bromodomain {1356-1426}
Ser phosphorylation site {S1468}
AT-rich interactive domain-containing protein 1A
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S79}
Ser phosphorylation site {S233}
Thr phosphorylation site {T286}
LXXLL {295-299}
Ser phosphorylation site {S363}
Ser phosphorylation site {S382}
glutamine-rich region {479-482}
MOTIF: glutamine residue (SEVERAL)
glutamine-rich region {561-567}
MOTIF: glutamine residue (SEVERAL)
Ser phosphorylation site {S604}
Ser phosphorylation site {S696}
Ser phosphorylation site {S698}
Ser phosphorylation site {S702}
Ser phosphorylation site {S764}
Ser phosphorylation site {S772}
serine-rich region {998-1001}
MOTIF: serine residue (SEVERAL)
ARID {1017-1108}
Ser phosphorylation site {S1184}
glutamine-rich region {1327-1404}
MOTIF: glutamine residue (SEVERAL)
LXXLL {1709-1713}
Ser phosphorylation site {S1755}
Ser phosphorylation site {S1944}
LXXLL {1967-1971}
LXXLL {2085-2089}
FACT complex subunit SPT16
COMPARTMENT: cell nucleus
MOTIF: coiled coil {432-507}
glutamate-rich region {926-1011}
MOTIF: glutamate residue (SEVERAL)
chromatin assembly factor 1 subunit A
COMPARTMENT: cell nucleus
MOTIF: binding site
SITE: 1-314
FOR-BINDING-OF: chromobox protein homolog 1
MOTIF: binding site
SITE: 1-49
FOR-BINDING-OF: proliferating cell nuclear antigen
Ser phosphorylation site {S65}
Ser phosphorylation site {S123}
Ser phosphorylation site {S138}
Ser phosphorylation site {S141}
Ser phosphorylation site {S143}
Ser phosphorylation site {S206}
Ser phosphorylation site {S224}
PxVxL {233-246}
lysine-rich region {323-453}
MOTIF: lysine residue (SEVERAL)
glutamate-rich region {602-608}
MOTIF: glutamate residue (SEVERAL)
homodimerization {642-678}
binding site
SITE: 60-956
FOR-BINDING-OF: chromatin assembly factor 1 subunit B
MOTIF: Thr phosphorylation site {T722}
Ser phosphorylation site {S772}
Ser phosphorylation site {S775}
Thr phosphorylation site {T865}
Ser phosphorylation site {S873}
glutamate-rich region {905-911}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S951}
topoisomerase-2 beta
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 182-187
Ser phosphorylation site {S431}
Thr phosphorylation site {T639}
Ser phosphorylation site {S640}
tyrosine residue {Y826}
nuclear export signal {1034-1044}
Ser phosphorylation site {S1236}
Ser phosphorylation site {S1336}
Ser phosphorylation site {S1340}
Ser phosphorylation site {S1342}
Ser phosphorylation site {S1344}
Ser phosphorylation site {S1400}
Ser phosphorylation site {S1413}
Ser phosphorylation site {S1454}
Ser phosphorylation site {S1466}
Ser phosphorylation site {S1471}
Ser phosphorylation site {S1522}
Ser phosphorylation site {S1524}
Ser phosphorylation site {S1526}
Ser phosphorylation site {S1550}
Ser phosphorylation site {S1552}
References
UnitProt :accession P51531
Components
actin-like protein 6A; 53 kD BRG1-associated factor A; actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K (ACTL6A, BAF53, BAF53A, INO80K)
AT-rich interactive domain-containing protein 1A; ARID domain-containing protein 1A; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; SWI/SNF complex protein p270; B120; SWI-like protein; Osa homolog 1; hOSA1; hELD; BRG1-associated factor 250; BAF250; BRG1-associated factor 250a; BAF250A (ARID1A, BAF250, BAF250A, C1orf4, OSA1, SMARCF1)
bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein, Williams syndrome transcription factor, hWALP2, BAZ1B, WBSC10, WBSCR9, WSTF)
chromatin assembly factor 1 subunit A; CAF-1 subunit A; chromatin assembly factor I p150 subunit; CAF-I 150 kDa subunit; CAF-Ip150 (CHAF1A, CAF, CAF1P150)
FACT complex subunit SPT16 (facilitates chromatin transcription complex subunit SPT16, hSPT16, FACT 140 kD subunit, FACTp140, chromatin-specific transcription elongation factor 140 kD subunit, SUPT16H, FACT140, FACTP140)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; global transcription activator SNF2L2; ATP-dependent helicase SMARCA2; SNF2-alpha; protein brahma homolog; hBRM; BRG1-associated factor 190B; BAF190B (SMARCA2, BAF190B, BRM, SNF2A, SNF2L2)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; transcription activator BRG1; ATP-dependent helicase SMARCA4; SNF2-beta; protein BRG-1; mitotic growth & transcription activator; protein brahma homolog 1; BRG1-associated factor 190A; BAF190A (SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; integrase interactor 1 protein; SNF5 homolog; hSNF5; BRG1-associated factor 47; BAF47 (SMARCB1, BAF47, INI1, SNF5L1)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI/SNF complex subunit SMARCC1; SWI/SNF complex 155 kD subunit; BRG1-associated factor 155; BAF155 (SMARCC1, BAF155)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI/SNF complex subunit SMARCC2; SWI/SNF complex 170 kD subunit; BRG1-associated factor 170; BAF170 (SMARCC2, BAF170)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; SWI/SNF complex 60 kD subunit; 60 kD BRG-1/Brm-associated factor subunit A; BRG1-associated factor 60A; BAF60A (SMARCD1, BAF60A)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BRG1-associated factor 57; BAF57 (SMARCE1, BAF57)
topoisomerase-2 beta (TOP2B)