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white sponge nevus of Cannon

Epidemiology: 1) rare 2) familial Pathology: - benign & permanent lesion - predominantly affects non-cornified stratified squamous epithelia - epithelial thickening, parakeratosis, & vacuolization of the suprabasal layer of oral epithelial keratinocytes Genetics: - autosomal dominant - associated with defects in KRT4 Clinical manifestations: 1) onset in adolescence or early adulthood 2) painless, soft, white, & spongy plaques in the oral mucosa 3) less frequently the mucous membranes of the nose, esophagus, genitalia & rectum are involved

Related

white lesions of the oral mucosa

General

nevus

Database Correlations

OMIM 193900

References

  1. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 204
  2. OMIM :accession 193900
  3. Songu M, Adibelli H, Diniz G. White sponge nevus: clinical suspicion and diagnosis. Pediatr Dermatol. 2012 Jul-Aug;29(4):495-7. Review. PMID: 22352924