Contents

Search

Womens Health Initiative (WHI) memory study

4532 women, age > 65 Testing with mini mental status exam (MMSE) annually Treatment group - Conjugated estrogens 0.625 mg QD - medroxyprogesterone 2.5 mg QD vs placebo. Study stopped prematurely in 2002 because risks outweighed benefit. Results: 1) 6.7% vs 4.8% declined > 2 standard deviations on MMSE 2) 31% increase in ischemic stroke (another arm of study)

General

clinical trial

References

  1. Prescriber's Letter 10(6):33 2003
  2. Journal Watch 23(13):101, 2003
  3. Shumaker SA et al, JAMA 289: 2651, 2003
  4. Rapp SR et al, JAMA 289:2663, 2003
  5. Wassertheil-Smoller S et al, JAMA 289:2673, 2003
  6. Yaffe K, JAMA 289:2717, 2003