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WAP, kazal, immunoglobulin, kunitz & NTR domain-containing protein 2 (WAP, follistatin, immunoglobulin, kunitz & NTR domain-containing-related protein, WFIKKN-related protein, growth & differentiation factor-associated serum protein 1, GASP-1, hGASP-1, WFIKKN2, GASP1, WFIKKNRP, UNQ9235/PRO31996)
Function:
- protease-inhibitor
- multiple distinct protease inhibitor domains
- probably has serine protease- & metalloprotease-inhibitor activity
- inhibits the biological activity of mature myostatin, but not activin (putative)
- interacts with both mature & propeptide myostatin/MSTN
Structure:
- belongs to the WFIKKN family
- contains 2 BPTI/Kunitz inhibitor domains
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Kazal-like domain
- contains 1 NTR domain
- contains 1 WAP domain
Compartment: secreted (putative)
Expression:
- primarily expressed in ovary, testis & brain, but not in liver.
- in fetal tissues, primarily expressed in brain, skeletal muscle, thymus & kidney
General
glycoprotein
secreted protein
serine protease inhibitor; serpin
Properties
SIZE: entity length = 576 aa
MW = 64 kD
COMPARTMENT: extracellular compartment
INHIBITS: serine protease
MOTIF: signal sequence {1-34}
WAP {42-91}
MOTIF: cysteine residue {C46}
MODIFICATION: cysteine residue {C79}
cysteine residue {C62}
MODIFICATION: cysteine residue {C83}
cysteine residue {C66}
MODIFICATION: cysteine residue {C78}
cysteine residue {C72}
MODIFICATION: cysteine residue {C88}
cysteine residue {C78}
MODIFICATION: cysteine residue {C66}
cysteine residue {C79}
MODIFICATION: cysteine residue {C46}
cysteine residue {C83}
MODIFICATION: cysteine residue {C62}
cysteine residue {C88}
MODIFICATION: cysteine residue {C72}
Kazal-type serine protease inhibitor domain {133-175}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
cysteine residue {C134}
MODIFICATION: cysteine residue {C164}
cysteine residue {C138}
MODIFICATION: cysteine residue {C157}
Reactive bond {140-141}
cysteine residue {C146}
MODIFICATION: cysteine residue {C175}
cysteine residue {C157}
MODIFICATION: cysteine residue {C138}
cysteine residue {C164}
MODIFICATION: cysteine residue {C134}
cysteine residue {C175}
MODIFICATION: cysteine residue {C146}
FOR-BINDING-OF: serine protease
immunoglobulin superfamily domain {210-303}
MOTIF: cysteine residue {C231}
MODIFICATION: cysteine residue {C287}
cysteine residue {C287}
MODIFICATION: cysteine residue {C231}
N-glycosylation site {N319}
BPTI/Kunitz inhibitor 1 {328-378}
MOTIF: cysteine residue {C328}
MODIFICATION: cysteine residue {C378}
cysteine residue {C337}
MODIFICATION: cysteine residue {C361}
cysteine residue {C353}
MODIFICATION: cysteine residue {C374}
cysteine residue {C361}
MODIFICATION: cysteine residue {C337}
cysteine residue {C374}
MODIFICATION: cysteine residue {C353}
cysteine residue {C378}
MODIFICATION: cysteine residue {C328}
BPTI/Kunitz inhibitor 2 {386-436}
MOTIF: cysteine residue {C386}
MODIFICATION: cysteine residue {C436}
cysteine residue {C395}
MODIFICATION: cysteine residue {C419}
cysteine residue {C411}
MODIFICATION: cysteine residue {C432}
cysteine residue {C419}
MODIFICATION: cysteine residue {C395}
cysteine residue {C432}
MODIFICATION: cysteine residue {C411}
cysteine residue {C436}
MODIFICATION: cysteine residue {C386}
NTR {445-566}
MOTIF: cysteine residue {C445}
MODIFICATION: cysteine residue {C515}
cysteine residue {C448}
MODIFICATION: cysteine residue {C517}
cysteine residue {C459}
MODIFICATION: cysteine residue {C566}
cysteine residue {C515}
MODIFICATION: cysteine residue {C445}
cysteine residue {C517}
MODIFICATION: cysteine residue {C448}
N-glycosylation site {N519}
cysteine residue {C566}
MODIFICATION: cysteine residue {C459}
Database Correlations
UniProt Q8TEU8
PFAM correlations
References
UniProt :accession Q8TEU8