WAP four-disulfide core domain protein 2 (major epididymis-specific protein E4, epididymal secretory protein E4, protease inhibitor WAP5, WFDC2 HE4 WAP5)

Function: putatative serine protease inhibitor Structure: contains 2 WAP domains Compartment: secreted Alternative splicing: named isoforms=5 Expression: - expressed in a number of normal tissues, including male reproductive system, regions of respiratory tract & nasopharynx - initially described as being exclusively transcribed in the epididymis Pathology: - highly expressed in a number of tumors cells lines, including ovarian, colon, breast, lung & renal cell lines

Properties

SIZE: MW = 13 kD entity length = 124 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-30} WAP 1 {32-74} MOTIF: cysteine residue {C36} MODIFICATION: cysteine residue {C62} N-glycosylation site {N44} cysteine residue {C45} MODIFICATION: cysteine residue {C66} cysteine residue {C49} MODIFICATION: cysteine residue {C61} cysteine residue {C55} MODIFICATION: cysteine residue {C70} cysteine residue {C61} MODIFICATION: cysteine residue {C49} cysteine residue {C62} MODIFICATION: cysteine residue {C36} cysteine residue {C66} MODIFICATION: cysteine residue {C45} cysteine residue {C70} MODIFICATION: cysteine residue {C55} WAP 2 {76-124} MOTIF: cysteine residue {C80} MODIFICATION: cysteine residue {C110} cysteine residue {C93} MODIFICATION: cysteine residue {C114} cysteine residue {C97} MODIFICATION: cysteine residue {C109} cysteine residue {C103} MODIFICATION: cysteine residue {C119} cysteine residue {C109} MODIFICATION: cysteine residue {C97} cysteine residue {C110} MODIFICATION: cysteine residue {C80} cysteine residue {C114} MODIFICATION: cysteine residue {C93} cysteine residue {C119} MODIFICATION: cysteine residue {C103} INHIBITS: serine protease

Database Correlations

UniProt Q14508 Pfam PF00095

References

UniProt :accession Q14508