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wee1 proto-oncogene protein

Function: - promotes inhibitory phosphorylation of p34cdc2 (CDK1) subunit of MPF on T14 & Y15 in yeast, only of Y15 in human (apparently a separate serine/threonine kinase phosphorylates T14 of CDK1 & CDK2)

Interactions

molecular events

General

tyrosine kinase (protein tyrosine kinase, PTK)

Properties

SIZE: MW = 49 kD STATE: active state MOTIF: Tyr phosphorylation site kinase domain SITE: C-TERMINAL MOTIF: ATP-binding site NAME: ATP-binding site Ser phosphorylation site Thr phosphorylation site

Database Correlations

OMIM 193525 UniProt P30291 Entrez Gene 7465

References

  1. Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell. 1991 Oct 4;67(1):197-211. PMID: 1913817
  2. Parker LL, Piwnica-Worms H. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science. 1992 Sep 25;257(5078):1955-7. PMID: 1384126
  3. Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9;374(6518):131-4. Review. PMID: 7877684