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WD repeat & FYVE domain-containing protein 1; FENS-1; phosphoinositide-binding protein 1; WD40- & FYVE domain-containing protein 1; zinc finger FYVE domain-containing protein 17 (WDFY1, KIAA1435, WDF1, ZFYVE17)
Function:
- binds PtdIns3P in vitro with high specificity
- less binding to other phosphoinositides
Structure:
- the FYVE-type Zn+2 finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes & penetrates bilayers
- the FYVE domain insertion into Ptdins(3)P-enriched membranes is substantially increased in acidic conditions
- contains 1 FYVE-type Zn+2 finger
- contains 7 WD repeats
Compartment: early endosomes
General
WD repeat protein family
zinc finger FYVE domain-containing protein (ZFYVE)
Properties
SIZE: MW = 46 kD
entity length = 410 aa
MOTIF: WD repeat {22-61}
WD repeat {66-105}
WD repeat {112-150}
WD repeat {153-192}
WD repeat {197-236}
WD repeat {240-279}
Zn finger Fyve-type
SITE: 281-352
EFFECTOR-BOUND: Zn+2
WD repeat {364-403}
Database Correlations
UniProt Q8IWB7
PFAM correlations
Entrez Gene 57590
Kegg hsa:57590
References
UniProt accession Q8IWB7