Wiskott-aldrich syndrome protein family member 2; WASP family protein member 2; protein WAVE-2; verprolin homology domain-containing protein 2 (WASF2, WAVE2)

Function: - downstream effector involved in signal tranduction from tyrosine kinase receptors & small GTPases to the actin cytoskeleton - binds actin & the Arp2/3 complex - interacts with BAIAP2 - component of the WAVE2 complex - directly interacts with C3orf10/HSPC300 Structure: - binds the Arp2/3 complex through the C-terminal region & actin through verprolin homology (VPH) domain - belongs to the SCAR/WAVE family - contains 1 WH2 domain Compartment: - cytoplasm, cytoskeleton (putative) - cell projection, lamellipodium (putative) - at the interface between the lamellipodial actin meshwork & the membrane (putative) Expression: - expressed in all tissues - strongest expression in placenta, lung, & peripheral blood leukocytes

General

phosphoprotein Wiskott Aldrich syndrome protein family (WASF)

Properties

SIZE: entity length = 498 aa MW = 54 kD COMPARTMENT: cytoplasm MOTIF: proline-rich region SITE: 268-271 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 318-328 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 333-338 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 347-350 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 364-371 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 379-382 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 391-406 MOTIF: proline residue (SEVERAL) WH2 {436-453} Ser phosphorylation site {S482} Ser phosphorylation site {S484} Ser phosphorylation site {S488} Ser phosphorylation site {S489}

Database Correlations

OMIM 605875 UniProt Q9Y6W5 Pfam PF02205 Entrez Gene 10163 Kegg hsa:10163

References

UniProt :accession Q9Y6W5