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Wiskott-aldrich syndrome protein family member 3; WASP family protein member 3; protein WAVE-3; verprolin homology domain-containing protein 3 (WASF3, KIAA0900, SCAR3, WAVE3)
Function:
- downstream effector involved in signal transduction from tyrosine kinase receptors & small GTPases to the actin cytoskeleton
- binds actin & the Arp2/3 complex
- required in the control of cell shape
- interacts with ABI2, KIFC3, RASL3, KANK2 & BYST [1]
Structure:
- binds the Arp2/3 complex through the C-terminal region & actin through verprolin homology (VPH) domain
- belongs to the SCAR/WAVE family
- contains 1 WH2 domain
Compartment: cytoplasm, cytoskeleton
Expression: expressed in ovary & brain
Pathology:
- may be overexpressed in chronic fatigue syndrome [2]
- overexpression
- can disrupt mitochondrial respiratory supercomplex formation
- is associated with endoplasmic reticulum stress
- associated with reduced complex IV levels in skeletal muscle mitochondria
General
Wiskott Aldrich syndrome protein family (WASF)
Properties
SIZE: entity length = 502 aa
MW = 55 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {57-93}
coiled coil {162-206}
proline-rich region
SITE: 304-310
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 343-350
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 395-410
MOTIF: proline residue (SEVERAL)
WH2 {440-457}
Database Correlations
OMIM 605068
UniProt Q9UPY6
Pfam PF02205
Entrez Gene 10810
Kegg hsa:10810
References
- UniProt :accession Q9UPY6
- Wang Pt, Ma J, Kim YC et al
WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in
myalgic encephalomyelitis/chronic fatigue syndrome.
Proc Natl Acad Sci U.S.A. 2023. 120(34):e2302738120 August 14.
https://www.pnas.org/doi/10.1073/pnas.2302738120