Wiskott-aldrich syndrome protein family member 1; WASP family protein member 1; protein WAVE-1; verprolin homology domain-containing protein 1 (WASF1, KIAA0269, SCAR1, WAVE1)

Function: - downstream effector involved in the signal transduction from tyrosine kinase receptors & small GTPases to the actin cytoskeleton - component of the WAVE1 complex - CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1 - binds actin & the Arp2/3 complex - interacts with BAIAP2 Structure: - binds the Arp2/3 complex through the C-terminal region & actin through verprolin homology (VPH) domain - belongs to the SCAR/WAVE family - contains 1 WH2 domain Compartment: - cytoplasm, cytoskeleton - dot-like pattern in the cytoplasm - concentrated in Rac-regulated membrane-ruffling areas Expression: - highly expressed in brain - lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine & peripheral blood

Properties

SIZE: entity length = 559 aa MW = 62 kD COMPARTMENT: cytoplasm MOTIF: proline-rich region SITE: 278-283 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 322-332 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 348-359 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 369-374 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 424-435 MOTIF: proline residue (SEVERAL) WH2 {497-514}

Database Correlations

OMIM 605035 UniProt Q92558 Pfam PF02205 Entrez Gene 8936 Kegg hsa:8936

References

UniProt :accession Q92558