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YL1 tumor suppressor protein (vacuolar protein sorting protein 72, transcription factor-like 1, protein YL-1, VPS72, TCFL1, YL1)
Function:
1) DNA-binding transcriptional regulator
2) chromatin modification & remodeling (putative)
3) phosphorylated upon DNA damage, probably by ATM or ATR
4) component of the NuA4 histone acetyltransferase complex
4) also part of a multiprotein complex which contains SRCAP & binds H2AFZ
Structure: belongs to the VPS72/YL1 family
Compartment: nucleus
General
anti-oncoprotein (tumor suppressor protein)
DNA-binding protein
phosphoprotein
Properties
SIZE: MW = 41 kD
entity length = 364 aa
COMPARTMENT: cell nucleus
MOTIF: acidic region {22-77}
MOTIF: acidic residue (SEVERAL)
DNA-binding motif
SITE: 156-206
MOTIF: Thr phosphorylation site {T168}
proline-rich region
SITE: 333-354
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 341-350
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 600607
UniProt Q15906
PFAM correlations
Entrez Gene 6944
Kegg hsa:6944
References
- OMIM :accession 600607
- UniProt :accession Q15906
Component-of
chromatin-remodeling SRCAP complex