vacuolar protein sorting-associated protein 37B (hVps37B) (VPS37B)

Function: - component of the ESCRT1 complex, a regulator of vesicular trafficking process - required for sorting of endocytic ubiquitinated cargos into multivesicular bodies - interacts with TSG101 Structure: belongs to the VPS37 family contains 1 VPS37 C-terminal domain Compartment: - cytoplasm - late endosome - peripheral membrane - recruited to the endosomal membrane (VPS4A-dependent) Expression: - widely expressed - expressed in macrophages & lymphocytes

General

membrane protein vacuolar protein sorting-associated protein (VPS)

Properties

SIZE: MW = 31 kD entity length = 285 aa COMPARTMENT: cytoplasm endosome MOTIF: VPS37 C-terminal {84-173} proline-rich region SITE: 170-280 MOTIF: proline residue (SEVERAL)

Database Correlations

UniProt Q9H9H4 Pfam PF07200

References

UniProt :accession Q9H9H4