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Vacuolar protein sorting-associated protein 37A (hVps37A, hepatocellular carcinoma-related protein 1, VPS37A, HCRP1)
Function:
- component of the ESCRT-1 complex
- required for sorting of endocytic ubiquitinated cargos into multivesicular bodies
- may be involved in cell growth & differentiation
- interacts with TSG101
Structure:
- belongs to the VPS37 family
- contains 1 VPS37 C-terminal domain
Compartment:
- cytoplasm
- late endosome membrane, peripheral membrane
- nucleus
Alternative splicing: named isoforms=3
Expression:
- widely expressed, more abundant in liver
Pathology:
- strongly decreased or undetected in hepatomas
General
vacuolar protein sorting-associated protein (VPS)
Properties
SIZE: MW = 44 kD
entity length = 397 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: VPS37 C-terminal {308-397}
Database Correlations
UniProt Q8NEZ2
Pfam PF07200
References
UniProt :accession Q8NEZ2