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vacuolar protein sorting-associated protein 35 (vesicle protein sorting 35, hVPS35, maternal-embryonic 3, VPS35, MEM3, TCCCTA00141)
Function:
1) component of the retromer complex
2) interacts directly with VPS26A & VPS26B
3) found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 & SFN
Compartment: cytoplasm, membrane, peripheral membrane
Alternative splicing: named isoforms=2
Expression:
- ubiquitous
- expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney, colon
- expression of protein inversely related to mRNA levels [2]
Pathology:
1) reduced expression occurs spatially and temporally in parallel with progression of Alzheimer's disease [2]
2) VPS35 regulates Abeta peptide levels
General
protein subunit
vacuolar protein sorting-associated protein (VPS)
Properties
SIZE: MW = 92 kD
entity length = 796 aa
Database Correlations
OMIM 606931
UniProt Q96QK1
Pfam PF03635
References
- UniProt :accession Q9UBQ0
- Small SA, Kent K, Pierce A, Leung C, Kang MS, Okada H,
Honig L, Vonsattel JP, Kim TW.
Model-guided microarray implicates the retromer complex in
Alzheimer's disease.
Ann Neurol. 2005 Dec;58(6):909-19.
PMID: 16315276
Component-of
retromer complex