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vacuolar protein sorting-associated protein 26A (vesicle protein sorting 26A, hVPS26A, VPS26A, VPS26)
Function:
1) component of the retromer complex
2) interacts directly with VPS35
3) found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35, SFN
Compartment:
- cytoplasm, endosome, endosomal membrane, peripheral membrane
Pathology:
1) down-regulated in Alzheimer disease, may be associated with down-regulation of the retromer complex
2) no polymorphism or variant associated with AD
General
protein subunit
vacuolar protein sorting-associated protein (VPS)
Properties
SIZE: MW = 38 kD
entity length = 327 aa
COMPARTMENT: endosome
Database Correlations
OMIM 605506
UniProt O75436
Pfam PF03643
References
- UniProt :accession O75436
Component-of
retromer complex