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protein VPRBP (HIV-1 Vpr-binding protein, VprBP, Vpr-interacting protein, DDB1- & CUL4-associated factor 1, VPRBP, DCAF1, KIAA0800, RIP)
Function:
- ubiquitin conjugation, 3rd step
- may act as a receptor for CUL4-DDB1 ubiquitin ligase complex
- interacts with DDB1, suggesting that it may participate to some RBX1-CUL4-DDB2 ubiquitin ligase complex
Structure:
- belongs to the VPRBP family
- contains 1 LisH domain
- although not canonical, the WD repeat-like region is related to WD repeats
Compartment: cytoplasm
Alternative splicing: named isoforms=3
Expression: ubiquitously expressed
Pathology:
- in case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr, possibly leading to hijack the RBX1-CUL4-DDB2 & arrest the cell cycle in G2 phase
- forms ternary complex with HIV-1 Vpr & DDB1
General
other protein
Properties
SIZE: MW = 169 kD
entity length = 1507 aa
COMPARTMENT: cytoplasm
MOTIF: LisH {846-878}
WD repeat-like {1091-1174}
acidic region {1396-1500}
MOTIF: acidic residue (SEVERAL)
Database Correlations
UniProt Q9Y4B6
Pfam PF08513
References
UniProt :accession Q9Y4B6