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protein Vpr (viral protein R, R ORF protein)
Function:
1) transport of the viral pre-integration complex to the nucleus during early stages of infection -necessary for viral infection of non-dividing macrophages.
2) anti-apoptotic effect, high level of expression induces apoptosis.
3) interacts with mitochondrial permeability transition pore complex (PTPC), presumably throughthe binding of ANT proteins -induces a rapid dissipation of the mitochondrial transmembrane potential
4) prevents infected cells from undergoing mitosis & proliferating, by inducing arrest or delay in G2 phase of cell cycle
5) interacts with COP6 Virion, nucleus, secreted protein
See Uniprot
General
retroviridae protein
Database Correlations
SWISS-PROT correlations
Pfam PF00522
References
UniProt :accession O12160