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vorinostat (Zolinza, SAHA)
Indications:
- advanced skin cancer
- cutaneous T-cell lymphoma [4]
- stage 3 or 4 mycoses fungoides [5]
Dosage: oral
Mechanism of action:
- histone deacetylase inhibitor; inhibits HDAC2
- enhances memory in mice [2]
General
histone decetylase inhibitor
antineoplastic enzyme inhibitor
Database Correlations
PUBCHEM cid=5311
References
- Prescriber's Letter 14(2): 2007
New drugs approved by the FDA in 2006
Detail-Document#: 2302213
(subscription needed) http://www.prescribersletter.com
- Guan J-S et al.
HDAC2 negatively regulates memory formation and synaptic
plasticity
Nature 2009 May 7; 459:55.
PMID: 19424149
- Graff J et al.
An epigenetic blockade of cognitive functions in the
neurodegenerating brain.
Nature 2012 Mar 8; 483:222
PMID: 22388814
- Deprecated Reference
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015