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voltage-gated K+ channel

Function: 1) establish resting membrane potential 2) modulate frequency & duration of action potential in neurons & muscle cells Structure: 1) four alpha subunits form a functional K+ channel 2) beta subunits are accessory (modulatory)

Related

K+ channel subfamily E member 1; K+ voltage-gated channel subfamily E member 1; IKs producing slow voltage-gated K+ channel subunit beta mink; minimal K+ channel; delayed rectifier K+ channel subunit IsK (KCNE1)

Specific

K+ voltage-gated channel subfamily KQT member 1; voltage-gated K+ channel subunit Kv7.1; IKs producing slow voltage-gated K+ channel subunit alpha KvLQT1; KQT-like 1 (KCNQ1, KCNA8, KCNA9, KVLQT1, KCNQ1OT1) voltage-gated K+ A channel (K+ channel IA , ISA, IA, A type K+ channel)

General

K+ channel multisubunit protein

Properties

COMPARTMENT: plasma membrane MOTIF: membrane region ION-PERMEABILITY: K+ SUBUNITS: voltage-gated K+ channel alpha subunit (4) MOTIF: transmembrane domain (6) H5 (K+) pore-forming region ION-PERMEABILITY: K+ voltage-gated K+ channel beta subunit MOTIF: phosphorylation site

References

  1. Kubo Y, Baldwin TJ, Jan YN, Jan LY. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature. 1993 Mar 11;362(6416):127-33. PMID: 7680768
  2. Martens JR, Kwak YG, Tamkun MM. Modulation of Kv channel alpha/beta subunit interactions. Trends Cardiovasc Med. 1999 Nov;9(8):253-8. Review. PMID: 11094335
  3. Chen X and Johnston D Properties of single voltgage-dependent K+ channels in dendrites of CA1 pyramidal neurones of rat hippocampus. J Physiol 2004, 559:187 PMID: 15218076

Components

voltage-gated K+ channel alpha subunit voltage-gated K+ channel beta subunit